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231832577 86214449 Proiect Poliartrita Reumatoida

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    UNIVERSITATEA ,,DUNREA DE JOS,, GALAI

    FACULTATEA DE MEDICIN I FARMACIE

    SPECIALIZAREA: ASISTEN MEDICAL GENERAL

    COORDONATOR TIINIFIC: ABSOLVENT:

    PROF. DR. RO CA TUDOR CRISTIAN ANTOHE GETA

    2011

    CUPRINS

    Intro!"#r# .... pag $

    PARTEA GENERAL ....... pag %C&'(to)!) I Et(o'&to*#n(& +n 'o)(&rtr(t& r#!&to(-...pag % I.1. Eti!gia ...... pag 10

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    I.". Patg#$ia ..... pag 10 I.%. A$at&i# pat!gi'( ...... pag 1.

    C&'(to)!) II E)##nt# # (&*no/t(" ( 'ro*no/t(" +n 'o)(&rtr(t&

    r#!&to(- .....................pag1

    II.1. )a$i*#+t(,i '!i$i'# pag 1 II.". )-i*i'(,i pa,a'!i$i'# .... pag 2 II.%. Diag$+ti' piti/ .. pag $$ II.0. Diag$+ti' -i*#,#$ia! . pag 31 II.2. C&p!i'aii ..pag 3$

    PARTEA SPECIAL.. pag 3CAPITOLUL III St!(! ")(n(" 'r(4(n 'ro*no/t("!) +n 'o)(&rtr(t&

    r#!&to(-55555555555555555555555555555555555555555555555555555555555555555555555555555555555555555pag III.1.E/a!3a,#a #/!3i#i 4i p,g$+ti'3!3i 5$ p!ia,t,ita ,#3&ati-( pag

    III.". O6i#'ti/3! '#,'#t(,ii . pag

    III.%. )at#,ia! 4i t-( .. pag

    III.0. A$a!ia g,a*i'a ........ pag

    Con")!6((........................pag

    ANE7E

    8I8LIOGRAFIE . pag

    3

    3

    1

    2

    %

    .$

    .

    Intro!"#r#

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    0

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    p,##$t 5$ &3!tip!# /a,ia$t#7 '##a '# -( -i*#,#$#!# -i$t,# i$-i/ii ?p!i&,*i+& a!#!i'@.

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

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    I525 P&to*#n(&

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    p,g,#+i/.

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

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    n poliartrita reumatoid#!# apa, 5$ '#! p3i$ %92 +t,at3,i 'a,#7 p,i$ p,!i*#,(,i 3!t#,ia,#7

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    'at 4i 5$ +8$g#7 *ii$- '#! &ai *,#'/#$t -# tip Ig) &ai ,a, -# tip IgG +a3 IgA.

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

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    E*#'t#!# #t,aa,ti'3!a,# +3$t -&i$at# -# p,##$a $-3!i!, ,#3&atii. C#!# &ai

    *,#'/#$t# !'a!i(,i 5$ ,-i$# -#+',#+'(ta,# +3$t '#!# p#,ia,ti'3!at# ?&ai a!#+ !a 't@7 +#,a+#

    ?p!#3,a7 p#,i'a,-@7 pa,#$'

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    I5$5 An&to(# '&to)o*("-

    P,i$'ipa!a !#i3$# 5$ p!ia,t,ita ,#3&ati-( #+t# o (n)&&;(# & /(no4(&)#( &rt("!)&;(()or

    (&rtro(&)#. Si$/it#i i +# -#+',i3 % 'a,a't#,# a$at&9pat!gi'# 'a,# '$',-( '3 #tap##/!3ti/# a!# 6!ii:

    a@ La i$'#p3t +i$/ita #+t# -# tip #-#&at+ '3 i$t#,#+a,# 5$ +p#'ia! a $#!, -# !a &a,gi$#a

    'a,ti!a;3!3i a,ti'3!a, 4i '3 #+3-a,# i$t,a'a/ita,(.

    6@ S# -#+',i# api p#,ia-( i$*i!t,ati/( 5$ 'a,# 'a!itat#a 4i 'a$titat#a '#!3!#!, +# &-i*i'( 5$

    ti&p. P!i$3'!#a,#!#7 'a,# !a i$'#p3t +3$t &ai $3,a+#7 +3$t 5$!'3it# -# !i&*'it#

    'a,# +3$t i$ +p#'ia! -# tip T

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    ',a$( -# !i&*'it#.

    N-3!ii ,#3&atii ',#+' p,i$ a'3&3!a,# -# '#!3!# p3t8$- a;3$g# !a -i+i3$i &a,i ?'&@

    4i pt *i &3!ti'#$t,i'i.

    F(*5 $ No!)( r#!&to(6( >ANE7E?

    25 Afectarea vascular de tip inflamator7 vasculitic, #+t# '&3$( -a, &-i*i'(,i!#

    i+'

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    CAPITOLUL II

    ELEMENTE DE DIAGNOSTIC I PROGNOSTIC

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    #p,#+ia i$*!a&ai#i +i$/ia!#i =%>.

    !rintre simptomele de debut, cel mai frecvent $nt%lnite sunt urmtoarele:

    ,#-a,# a,ti'3!a,( &ati$a!( p,#!3$git(

    p!ia,t,a!gii #pi+-i'# t3*i#,i a,ti'3!a,#

    &ia!gii

    +!(6i'i3$# &3+'3!a,( 5$ +p#'ia! !a 3,i

    6+#a!(

    pi#,-#,# p$-#,a!(

    +ta,# -# -i+'$*,t.

    F(* nr5 3 C&rt()&@ /#";(!n#

    A'#+t#a apa, 5$ +3''#+i3$i7 '&6i$aii7 -3,at# +i i$t#$+it(i /a,iat#. I$+ta!a,#a7 '#! &ai

    -#+#,i7 #+t# g,a-at(7 #a *8'8$-39+# 5$ !3$i7 &ai ,a, 5$ a$i. D#63t3! a'3t7 *3!&i$a$t7 $3 #+t#

    *,#'/#$t '8$- +# p,-3'#7 #! apa,# &ai a!#+ !a 'pi!.

    E/!3ia +3*#,i$#i !'a!# #+t# 3$#,i -#+t3! -# ,api-(7 ia, '8$- +# a-a3g( *#6,a 4i+a3

    pi#,-#,#a p$-#,a!(7 ,i#$ta,#a -iag$+ti'( #+t# &ai 34a,(.

    Di$t,# #!#$t#!# '!i$i'# 'a,a't#,i+ti'# -#63t3!3i7 &a,# /a!a,# -iag$+ti' a,#

    +it,ia +3*#,i$#i a,ti'3!a,# 4i ,#+p#'ta,#a a,ti'3!aii!, i$t#,*a!a$gi#$# -i+ta!# =">.

    Artritelea3 a$3&it# pa,ti'3!a,it(i tpg,a*i'#.

    Articulaiile m%inii7 '#a ,a-i'a,pia$(7 g#$3$'

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    -#+ i$t#,#+at#7 -a, p!ia,t,ita ,#3&ati-( pat# a*#'ta ,i'# a!t( a,ti'3!ai# -ia,t,-ia!(.

    Fapt3! 'a +i$/ita #+t# '$+i-#,at( #!#$t3! '

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    21/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    Articulaiilepiciorului+3$t -#+#,i ati$+# !a i$'#p3t3! 6!ii +i&3!ta$ '3 '#!# a!# &8i$ii.

    S3$t a*#'tat# &ai a!#+ a,ti'3!aii!# tata,+*a!a$gi#$# ?*ig. $,. @.

    E,i3$i!# 'a,ti!a;#!, +i -#*,&(,i!# a,ti'3!a,# '$+#'3ti/# -#t#,&i$( g,#3tat# !a ,+.

    $ a'#!a4i ti&p p,#+i3$#a ##,'itat( -# g,#3tat#a ',p,a!( #+t# ,#-i+t,i63it( $#*ii!gi'p# +3p,a*aa t(!pii7 '##a '# -3'# !a apa,iia -# -3,ia$# p!a$ta,#7 a&p!i*i'8$- a+t*#! ,+3! -i*i'i!.

    Di$t,# a,ti'3!aii!# ta,+3!3i '#a a+t,aga!9'a!'a$#a$( 4i '#a a+t,aga!9+'a*i-ia$( +3$t

    i$t#,#+at# &ai -#+.

    F(*5 nr5 . Mo(("-r( &)# &rt("!)&;(()or #t&t&r/o&)&n*(#n#

    A!(t3,i -# a*#'ta,#a g!#$#!, -at( -# #,i3$i!# 'a,ti!agi$a+#7 t#$+i$/it#!#

    ,#t,&a!#!a,# #t#,$# 4i i$t#,$# pa,ti'ip( !a i$-3'#,#a 3$3i ,+ i$+ta6i!.

    D#+t3! -# -#+ +# p,-3'# 63,+ita ,#t,'a!'a$#a$(.

    (enunchii +3$t *a,t# *,#'/#$t a*#'tai7 +i$/ita *ii$- !a i$'#p3t #+3-ati/( 4i api

    p,!i*#,ati/(. E,i3$i!# 'a,ti!agi$a+# 4i a!# +3!3i +3$t 5$+( &ai ta,-i/# 4i -# i$t#$+itat# &ai

    &i'( ?*ig. $,. @.

    "1

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    F(*5 nr5 % Mo(("-r( &)# &rt("!)&;(#( *#n!n"B(!)!( >/#"B#)#?

    Artr(t& #oldului?'ita@ $3 #+t# *,#'/#$t(. Ea +# &a$i*#+t( '!i$i' &ai a!#+ p,i$ -i*i'3!tat#!a ,+.

    A#"t&r#& articulaiilor coloanei vertebrale #+t# ,a,(. C8$- +# p,-3'#7 +#g$t3!

    '#,/i'a! +3*#,( '#! &ai -#+. I$*!a&aia &i'ii 63,+# 'a,# +# ,#g(+#4t# 5$t,# ai+ 4i !iga$t3!

    t,a$+/#,+ pat# -#t#,&i$a +36!3aii 5$ a,ti'3!aia at!a$t9ai-ia$(. D3,#,i!# '#,/i'a!# 5$a!t# 4i

    &ai a!#+ '#!# '#,/i'''ipita!# pt +3g#,a a'#a+t( 63,+it(.

    A,t,ita a,ti'3!aii!, i$t#,ap*ia,# +# p,-3'# &ai a!#+ 5$t,# /#,t#6,#!# C%7 C07 C2 4i pat#

    *i 'a3a -# +p$-i!!i+t#i+.Artr(t& temporo)mandibular #+t# *,#'/#$t(7 -a, ,a,#,i #+t# g,a/( 5&pi#-i'8$-

    a!i$ta,#a. $t,# a,ti'3!aii!# i$t#,#+at# '#! &ai ,a, +# $3&(,( '#!# ',i'a,t#$i-i#$#7

    +t#,$'!a/i'3!a,#7 a',&i'!a/i'3!a,#7 -at,it( #i+t#$#i 3$#i +i$/ia!# ,#-3+#.

    D#4i #+t# 6a!( p,#-&i$a$t a,ti'3!a,(7 5$ ti&p3! #/!3i#i #i +# pt 5$ta!$i 4i &a$i*#+t(,i

    #t,aa,ti'3!a,# -#t#,&i$at# -# i$*i!t,at# !i&*p!a+&'ita,# ?3$#,i ,ga$iat# 5$ $-3!i@ 4i+a3 -#

    ""

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    p,'#+# /a+'3!iti'#.

    A'#+t# &-i*i'(,i .

    Fa,t# ,a, +# p,-3'# /a+'3!ita ',$a,( '# +# pat# &a$i*#+ta '!i$i' p,i$ -i/#,+# g,a-# -#

    i$+3*i'i#$( ',$a,ia$(7 ,g8$- p8$( !a i$*a,t &i'a,-i' a'3t.

    "%

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    24/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    A,t#,#!# p#,i*#,i'# pt *i +#-i3! 3$, p,'#+# -# /a+'3!it( 6!it#,a$t(. C8$- #+t# !'a!iat(

    !a /a+#!# -igita!#7 &-i*i'(,i!#

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    25/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    p,i$ t,a$+pa,#$( a ',i-#i. A'#a+ta #+t# p+i6i! -at,it( +36i#,ii +'!#,#i p,i$ -i+t,3'ia t#t3,ii

    +a!# 4i 34a,a

    K 7 ia, !a '#!# ,#'ta!# !a 2 K -i$t,# 6!$a/i. C#! &ai -#+ #p,#+ia +a '!i$i'( #+t# -# ,-i$ ,#$a!.

    II5 25 Mo(("-r( '&r&")(n("#

    D#4i apa, &ai t8,i3 5$ #/!3ia 6!ii7 #!# pt a;3ta !a ,#!/a,#a 3$3i -iag$+ti'

    -i*#,#$ia!.

    E7AMENE DE LA8ORATOR

    VS

    Di$t,# a$&a!ii!#

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    26/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    D#t#r(n&r#& VS

    P,#!#/a,#a p,6#!, 9 +# ,#'!t#a( +8$g# /#$+ 5$ /a'3t(i$#,# +p#'ia!# p#$t,3 VSH:

    #p,36#t( '3 *3$-3! p!at7 'a,# '$i$# 'it,at -# +-i3 %7JK 4i 'a,# p#,&it 3&p!#,#a a'#+t#ia '3 "70&! +8$g#7 ,#+p#'t8$- a+t*#! p,p,ia +8$g#9a$ti'ag3!a$t -# 0:1.

    T,a$+p,t3! p8$( 5$ !a6,at, +# a+ig3,a 5$ t36 p,i&a, 5$ '#! &ai +'3,t ti&p.

    I-iat 5$ai$t# -# t#+ta,# +# &i#a( t363! '3 at#$i# p,i$ ,(+t3,$a,# &i$i& -# 'i$'i ,i.

    S# p!a+#a( t363! 5$ +tati/3! -# &a+3,a,# a+ig3,8$-39$# '( $i+'3! +3p#,i, #+t# !a

    $i/#!3! #,. Di+ta$a -i$t,# $i+' 4i 6aa t363!3i t,#63i# +a *i# 22 && ?291 &&@. S# p!a+#a(

    +tati/3! !a t#&p#,at3,a 'a,#i p# +3p,a*a( ,i$ta!a *(,( /i6,aii.

    Citi,#a VSH7 +# *a'# -3p( 1< -i,#'t 5$ && X#+t#,g,##$,(.

    S'a!a +tati/3!3i #+t# $3,tat( -# !a !a 107 *i#'a,# -i/ii3$# ',#+p3$8$- !a 2 3$it(i

    X#+t#,g,#$ ?1 3$itat# X#+t#,g,##$1&& ,a@.

    An#(& -# g,a- '!i$i' -i3 #+t# p,##$t( !a p#+t# "2K -i$t,# 6!$a/i. Ea pat# *i

    5$t8!$it( 5$ p#,ia-#!# -# a'ti/itat# a 6!ii7 &ai a!#+ !a 6!$a/ii *#6,i!i +a3 !a '#i '3 ati$g#,i

    p!ia,ti'3!a,# ?*ig. $,. J@.

    A$#&ia ?-# tip $,&'ita,7 $,&',& +a3 .

    "

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    F(*5 nr5 An#(&

    E*#'t3a,#a

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    -i+t,3'ti/ ti+3!a, i$*#'i+ +a3 $#i$*#'i+.

    $ -i*#,it# '$-iii pat!gi'#7 /a!a,#a CRP pat# ',#4t# 5$ $3&ai 1"9"0 -# ,# -# p#+t#

    % -# ,i *a( -# $,&a!7 *ii$- p,##$t( 5$ +#, +a3 a!t# !i'

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    29/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    T#+t3! -# *a't, ,#3&ati- &(+a,( 'a$titat#a -# a$ti',pi ai a'#+t3ia -i$ p!a+&(

    +a$g3i$(7 p,##$i !a &a;,itat#a '#!, a*#'tai -# a,t,ita ,#3&ati-(.

    A$ti',pii +3$t p,-34i -# +i+t#&3! i&3$ita, p#$t,3 a a;3ta !a -i+t,3g#,#a 6a't#,ii!, 4i

    /i,3+3,i!, '# pt 'a3a -i*#,it# a*#'i3$i.Fa't,3! ,#3&ati- #+t# 3$ a$ti',p7 '# +# pat# ata4a -# '#!3!#!# +($ata+# a!#

    ,ga$i+&3!3i7 ,#3!t8$- -i+t,3g#,#a a'#+t,a.

    U$ tit,3 ',#+'3t a! *a't,3!3i ,#3&ati- pat# *i -at -# +#,i# -# a*#'i3$i a3ti&3$#

    ?i$'!3+i/ a,t,ita ,#3&ati-(@ 4i -# +#,i# -# i$*#'ii +#/#,#. $ &- 'ai$a!7 ',#4t#,# a

    *a't,3!3i ,#3&ati- pat# ap(,#a 4i 5$ 'a3! p#,+a$#!, +($(ta+#.

    FRpat# +( apa,( 4i 5$t,9 +#,i# -# '!ag#$# 9 !3p3+ #,it#&at+ +i+t#&i'7 +'!#,-#,&i#7

    -#,&at&iit(7 6!i i$*#'ia+# ?+i*i!i+7 t36#,'3!(7

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    30/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    C#,'#ta,#a )("B(!)!( /(no4(&)a,at( 3$ !i'

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    31/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    F(*5 nr5 10 Artro/"o'(&

    Artro/"o'(& a,# /a!a,# -iag$+ti'( !i&itat(. S# ,#'&a$-( &ai &3!t p#$t,3 a +#

    ap,#'ia #t#$+ia !#i3$i!, 5$ /#-#,#a #/a!3(,ii 4i ap,#'i#,#a *#!3!3i p#,ai#i ?*ig. $,. 1@.

    E=n# R&(o)o*("#

    adiografia osteoarticulara,# p$-#,# -iag$+ti'( &a,#7 &ai a!#+ 5$t,93$ '$t#t '!i$i'+3g#+ti/. $ #a&i$a,#a 3$#i ,a-ig,a*ii +# 3,&(,#4t#:

    t3*i#,#a p(,i!, &i p#,ia,ti'3!a,# a!# a,ti'3!aii!, p#,i*#,i'# 'a,# #+t# p,#''# 4i

    p,#'#-# &-i*i'(,i!# 'a,ti!agi$a+# 4i +a+# +# p,-3'# p,i$ a'3&3!a,# -# !i'

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    F(*5 nr

    F(*5 nr5 11 R&(o*r&(( o/t#o&rt("!)&r#

    #,i3$i!# &a,gi$a!# ,#p,#i$t( '#! &ai 'a,a't#,i+ti' +#&$ a! 6!ii +# p,-3' !a !'3!

    -# i$+#,i# a! +i$/ia!#i p# 'a,ti!a; 4i +3$t 3,&a,#a ,#+,6i#i +a+# p,-3+# +36

    i$*!3#$a -# /#'i$(tat# a pa$3+3!3i. I&agi$#a ,a-ig,a*i'( a #,i3$i!, #+t# -# g#-#$

    +a3 p+#3-'

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    33/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    at!a$t9aia!(7 -at,at# !ait(ii +a3 ,3pt3,ii !iga$t3!3i t,a$+/#,+ a! at!a+3!3i +a3 #,i3$i!,

    +3*#,it# -# ap*ia -$ti-( a ai+3!3i.

    $ '#!#!a!t# a,ti'3!aii +# pt 5$+',i# !#i3$i -# i$t#$+it(i -i*#,it#7 5$ *3$'i# -# ti&p3! -#

    #/!3i# +i -# g,a-3! -# ag,#+i/itat# a 6!ii.$ p!ia,t,it#!# +#,$#gati/# +3*#,i$a a,# &ai *,#'/#$t 3$ -#63t a+it,i' '3 i$t#,#+a,#a

    p,#-&i$a$t( a 'a,p3!3i. E,i3$i!# +36'$-,a!# +3$t &ai ,#-3+#7 ia, ,#a'ia ,#pa,at,i#

    +t#+'!#,ti'( +36'$-,a!( #+t# &ai i$t#$+(.

    T,#63i# +36!i$iat *apt3! '( -#4i &-i*i'(,i!# +t,3't3,a!# a!# 'a,ti!a;3!3i +# p,-3' ti&p3,i37

    3$#,i +36 3$ a$ -# !a -#63t3! 6!ii7 +#&$#!# ,a-i!gi'# -#/i$ /ii6i! &3!t &ai t8,i3 3$#,i

    -3p( 19" a$i. P,i!# a!t#,(,i 'a,ti!agi$a+# pt *i 5$+( +#+ia6i!# p,i$ ,#$a$( &ag$#ti'(

    $3'!#a,(

    .

    $ '#!#!a!t# a,ti'3!aii +# pt 5$+',i# !#i3$i -# i$t#$+it(i -i*#,it#7 5$ *3$'i# -# ti&p3! -#

    #/!3i# +i -# g,a-3! -# ag,#+i/itat# a 6!ii.

    $ p!ia,t,it#!# +#,$#gati/# +3*#,i$a a,# &ai *,#'/#$t 3$ -#63t a+it,i' '3 i$t#,#+a,#a

    p,#-&i$a$t( a 'a,p3!3i. E,i3$i!# +36'$-,a!# +3$t &ai ,#-3+#7 ia, ,#a'ia ,#pa,at,i#

    +t#+'!#,ti'( +36'$-,a!( #+t# &ai i$t#$+(.

    T,#63i# +36!i$iat *apt3! '( -#4i &-i*i'(,i!# +t,3't3,a!# a!# 'a,ti!a;3!3i +# p,-3' ti&p3,i37

    3$#,i +36 3$ a$ -# !a -#63t3! 6!ii7 +#&$#!# ,a-i!gi'# -#/i$ /ii6i! &3!t &ai t8,i3 3$#,i

    -3p( 19" a$i. P,i!# a!t#,(,i 'a,ti!agi$a+# pt *i 5$+( +#+ia6i!# p,i$ ,#$a$( &ag$#ti'(

    $3'!#a,(.

    %%

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    34/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    II5 $5 D(&*no/t(" 'o6(t(4

    -iagnosticul de poliartrit reumatoid$#'#+it( '$*i,&a,#7 +!i'it( -i*#,#$i#,#a -# a!t#

    +3*#,i$# '3 'a,# a, a/#a p3$'t# '&3$# 4i i&p3$# ap,#'i#,#a +ta-i3!3i -# #/!3i# 4i -# a'ti/itat#a! 6!ii ?*ig. $,. 1"@.

    -iagnosticul pozitiv#+t# 34, -# *('3t 5$ +ta-ii!# a/a$+at# a!# 6!ii7 a+p#'t3! '!i$i' 4i '#!

    ,a-i!gi# *ii$- +3*i'i#$t -# +3g#+ti/.

    F(*5 nr5 12 D(&*no/t("!) # 'o)(&rtr(t- r#!&to(-

    U$ -iag$+ti' p,#''# #+t# 5$+( *a,t# 3ti!7 -#a,#'# &(+3,i!# t#,ap#3ti'# pt +( *i#

    i$+tit3it# ,api-7 i&pi#-i'8$-39+# a+t*#! apa,iia !#i3$i!, +p#'i*i'# 6!ii 'a,# -# 6i'#i +3$t

    i,#/#,+i6i!#.

    Fa,t# -#+ -#63t3! ,#a! a! 6!ii #+t# ig$,at -# 6!$a/7 #! *ii$- '3 -i*i'3!tat# ,#'$+tit3it-3p( p#,ia-a -# #/!3i# &ai a!#+ '( -at#!# -# !a6,at, +3$t *a,t# ,a, &-i*i'at#7 !a 5$'#p3t3!

    6!ii 4i 5$ p!3+ a3 3$ &a,# g,a- -# $#+p#'i*i'itat#.

    C#)# &( r#"4#nt# o(("-r( ")(n("# # #9!t /!nt:

    p!ia,t,ita i$t#,&it#$t( +a3 p#,+i+t#$t( !a 3$ $3&(, !i&itat -# a,ti'3!aii '# p(+t,#a(

    %0

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    'a,a't#,3! +p#'i*i' a! +it,i#i a,ti'3!aii!# '#!# &ai -#+ i$t#,#+at# !a -#63t +3$t '#!# a!#

    &8i$ii +a3 '#!# a!# pi'i,3!3i

    a,t,ita ',$i'( p,g,#+i/( -#*,&a$t(7 'a,# 5$'( -# !a 5$'#p3t a,# #/!3i# ,api-( 4i

    g,a/( p!ia,t,ita a'3t(7 #p!i/( 4i &ig,at,i#7 *a,t# a+#&($(ta,# ,#3&ati+&3!3i a,ti'3!a, a'3t

    B3i!!a3-

    ,#3&ati+&3! p!i$-,&i'

    5$ ti&p3! ;3/#$i!7 -#63t3! pat# *i pa3'ia,ti'3!a, 4i a+it,i'

    5$ 'a3! -#63t3!3i !a /8,+t$i'7 ?-3p( /8,+ta -# a$i@ ati$g#,#a a+it,i'( a 3$3i $3&(,

    &i' -# a,ti'3!aii #+t# &ai *,#'/#$t(. S# +#&$a!#a( a*#'ta,#a 5$t,9 i$'i-#$( +3p#,ia,( a

    a,ti'3!ai#i 3&(,3!3i

    -#63t3! !iga,ti'3!a,7 -a, &ai a!#+ '#! /i+'#,a! +# i$t8!$#+' &ai ,a,.

    P#$t,3 +t3-ii pp3!ai$a!# *('3t# 5$ +'p -# '#,'#ta,#7 A/o"(&;(& A#r("&n&- #

    R#!&to)o*(# >ARAA#r("&n RB#!&t(/ A//o"(&t(on?a +ta6i!it +#,i# -# ',it#,ii '!i$i'#7

    6i!gi'#7

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    -i$t,# a'#+t# ',it#,ii.

    E7AMENE DE LA8ORATOR

    P,i&3! #!#$t a3t,#a'ti/ i-#$ti*i'at 5$ +#,3! pa'i#$i!, '3 p!ia,t,it( ,#a'ti/( a *+t*a't,3! ,#3&ati- ?FR@7 3!t#,i, *ii$- -#*i$it 'a 3$ a3ta$ti',p +p#'i*i' a$ti9i&3$g!63!i$a G.

    Di$ 107 '8$- E&i! Xaa!#, a -#+',i+ i$iia! FR7 5$ +#,3! pa'i#$i!, '3 PAR a3 *+t g(+ii

    $3,4i a!i a3ta$ti',pi 'a,# a'i$#a( a+3p,a -i/#,+#!, '&p$#$t# ti+3!a,#9i$t( ?-# #.

    '!ag#$3! 4i a!t# p,t#i$# '&p$#$t# a!# #+3t3!3i 'a,ti!agi$+7 p,t#i$# -# 4' t#,&i'7 #$i

    p,t#i$# $3'!#a,# 4i p,t#i$# 'it,3!i$at# '3& a, *i *i6,i$a +a3 /i$ti$a@.

    Di$t,# a$ti',pii -#t#'tai 5$ +#,3! pa'i#$i!, '3 PAR7 a$ti',pii a$tip,t#i$( 'it,3!i$at(

    ?ACPA@ a3 +p#'i*i'itat# &ai ,i-i't(7 5$ ti&p '# a!i a3ta$ti',pi7 i$'!3+i/ FR7 apa, &ai *,#'/#$t 4i

    5$ a!t# 6!i +a3 '

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    pa'i#$ii '3 PAR !a -#63t.

    FR9Ig) $3 +3$t +p#'i*i'i p#$t,3 PAR7 *ii$- -#t#'tai 5$ tit,3 &a,# !a &a;,itat#a

    pa'i#$i!, '3 +i$-,& S;g,#$ p,i&a, +a3 ',ig!63!i$#&i# &it( 4i 5$ tit,3,i +'(3t# 5$ a!t#

    a*#'i3$i ,#3&at!gi'#. Tt34i7 +p#'i*i'itat#a FR p#$t,3 PAR ',#4t# '$+i-#,a6i! -at( '3',#4t#,#a tit,3!3i7 3$ FR &ai &a,# 'a 2 UI&L7 *ii$- +p#'i*i' p#$t,3 p!ia,t,ita ,#3&ati-(.

    C3 tat# a'#+t#a7 FR 2 UI&L +# g(+#4t# -a, !a 'i,'a 2K -i$ pa'i#$ii '3 PR !a

    -#63t7 '8$- ',it#,ii!# -# -iag$+ti' p#$t,3 PAR $3 +3$t '&p!#t 5$t,3$it#. FR -# tat# +36tip3,i!#

    pt *i p,##$t# -#;a 5$ +ta-ii!# p,#''# -# 6a!(7 3$#,i p,#'#-8$- -#63t3! PAR '3 '8i/a a$i.

    U$#!# +t3-ii +3g#,#a( '( FR9Ig A a, *i 3$ a$ti',p9&a,#, &ai +p#'i*i' p#$t,3 PAR -#'8t

    +36tip3,i!# FRIg ) +i FR9Ig G. E+t# i&p,ta$t -# 4ti3t '( tit,3,i ,i-i'at# -# FR9Ig ) 4i FR9Ig A

    a3 4i /a!a,# p,g$+ti'( '$+i-#,a6i!(7 *ii$- a+'iai '3 *, +#/#,# -# PAR7 '3 #,i3$i

    #/i-#$t# ,a-i!gi'#7 a*#'i3$i &ai ,api- p,g,#+i/#7 &a$i*#+t(,i #t,a9a,ti'3!a,# '3 p,g$+ti'

    +'(3t.

    Ant("or'(( &nt('rot#(n# "(tr!)(n&t# ?ACPA 9 A$ti9Cit,3!!i$at#- P,t#i$ A$ti6-i#+@7

    ,#+p#'ti/ a$ti',pii a$ti p#pti- 'i'!i' 'it,3!i$at ?a$ti9CCP 9 C'!i' Cit,3!!i$at#- P#pti-#@.

    U$a -i$t,# '#!# &ai +p#'ta'3!a+# -#+'p#,i,i 4tii$i*i'# 5$ '#,'#ta,#a a*#'i3$i!,

    a3ti&3$# -i$ 3!ti&ii #'# a$i a *+t i-#$ti*i'a,#a 5$ +#,3! pa'i#$i!, '3 PAR a 3$,

    a3ta$ti',pi +p#'i*i'i p#$t,3 #pitpii '$i$8$- 3$ a'i- a&i$'it,3!i$i' $#6i4$3it7 g#$#,at p,i$-#i&i$a,# p+tt,a$+!ai$a!( a ,#i-33,i!, a,gi$i! +36 a'i3$#a #$ii p#pti-i!9

    a,gi$i$-#!i&i$aa ?PADI@.

    A!to&nt("or'(( 'a,# ,#'3$+' #pitpii 'it,3!i$ai +3$t '3$+'3i +36 -#$3&i,#a -#

    a$ti',pi a$tip,t#i$# 'it,3!i$at# ?ACPA@. Epitpii 'it,3!i$ai a3 *+t i$iia! i-#$ti*i'ai 5$

    *5!ag,i$(7 p,t#i$( p,##$t( #'!3+i/ 5$ '#!3!#!# #pit#!ia!# +'3a&a+#.

    E+t# i$t#,#+a$t -# 4ti3t '( *i!ag,i$a '$+tit3i# a$tig#$3! i$t( a! a$ti',pi!, a$ti9#,ati$a7

    -#+',i4i '3 &3!t ti&p 5$ai$t# 'a a/8$- +p#'i*i'itat# ,i-i'at( 5$ PAR7 #/i-#$iai p,i$

    i&3$*!3,#+'#$a i$-i,#'t( 4i '3$+'3i 5$'( -i$ 1 'a a$ti',pi a$ti9a$tig#$# p#,i$3'!#a,#.

    F()&*r(n& 5$+( $3 ,#p,#i$t( 3$ '$+tit3#$t a,ti'3!a,7 *ii$- &ai -#g,a6( 3$ a$tig#$ '3

    ,#a'ti/itat# 5$',3'i4at( -#'8t +t,3't3,( i$t( p,i&a,( a ACPA. U$ a!t a$tig#$ p+i6i! #+t# *i6,i$a7

    -a, 4i p,#'3,+,3! +a3 9 *i6,i$g#$3!7 *,!# 'it,3!i$at# a!# a'#+t#i p,t#i$# *ii$- i-#$ti*i'at# 5$

    #+3t3! +i$/ia! a! pa'i#$i!, '3 PR +a3 a!t# a,t,it#.

    %

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    La &a;,itat#a pa'i#$i!, '3 PAR7 *i6,i$g#$3! 'it,3!i$at pa,# a *i 3$ a$tig#$ i$t(

    -&i$a$t a! '#!3!#!, B. A!t a$tig#$ -# &a,# i$t#,#+ #+t# /i$ti$a 9 p,t#i$a -# 'it+'

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    39/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    C8t#/a +t3-ii a3 +ta6i!it ',#!ai# +#&$i*i'ati/( 5$t,# p,##$a ACPA 4i p,g,#+ia

    ,a-i!gi'( a 6!ii ?a !#i3$i!, +a+#@.

    )ai &3!t7 ACPA +# a+'ia( +#&$i*i'ati/ '3 p,##$a a!#!#!, HLA9DR +p#'i*i'#

    p!ia,t,it#i ,#3&ati-#. P3,t(t,ii -# ACPA '3 HLA9DR a3 3$ ,i+' ',#+'3t p#$t,3 a -#/!ta*, +#/#,# -# PAR.

    $ '$'!3i#7 ACPA +3$t a$ti',pii &a,#, '#i &ai /a!,4i 4i -#t#,&i$a,#a !, #+t#

    -#+#6it -# 3ti!( 5$ 'a3! pa'i#$i!, '3 a,t,it( !a -#63t '8$- $3 +3$t 5$-#p!i$it# tat# ',it#,ii!#

    p#$t,3 PAR="J>.

    A!to&nt("or'(( &nt(RA$$

    A3ta$ti',pii a$ti9RA%% +3$t -i,#'i$ai 5&pt,i/a 3$, ,i6$3'!#p,t#i$# $3'!#a,#

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    40/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    A);( &!to&nt("or'(

    Ant("or'( &nt("o)&*#nA$ti',pii a$ti9'!ag#$ II +3$t p,##$i 5$ !i'

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    41/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    Ant("or'( &nt(*)!"o6-. o/&t (6o#r&6&?GPI 9 g!3'+#9 p

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    42/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    ,# +a3 i!#7 '3 V.S.H. $,&a!a@ #t'.

    C#)# &( r#"4#nt# "on!6((+# ',##a( '3 +p$-i!ita a$'

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    43/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    !3pi'(.

    $ 'a3! 5$ 'a,# +i$-,&3! ,#3&ati- apa,# 5$ 'a-,3! a!t, 6!i 'a +a,'i-a7 a&i!i-a7

    6!i i$*!a&ata,# -ig#+ti/#7 6!i i$*#'ia+# ?

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    PARTEA SPECIAL

    CAPITOLUL IIISTUDIU CLINIC PRIVIND PROGNOSTICUL

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    D3pa i$t#,/a!3! -# ti&p i$ 'a,# +# i$+ta!#aa a$'

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    47/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    %. E/a!3a,#a +tat3+3!3i 'a$i' a,ti'3!a,: pi#,-#,#a &6i!itatii i$+ta6i!itat# a,ti'3!a,a -#aa,#

    a,ti'3!a,a -#*,&a,# a,ti'3!a,a.

    0. P,##$ta &a$i*#+ta,i!, #t,aa,ti'3!a,#

    2. E/a!3a,#a g!6a!a a 6!ii ?pa'i#$t-i'@. P,##$ta 'a*#'ta,i!, &,6i-#

    . Ap,#'i#,#a g,a-3!3i -# a'ti/itat# a 6!ii ?,#a'ta$ti -# *aa a'3ta7 *a't,i ,#3&atii@

    J. E/a!3a,#a *3$'ti#i

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    48/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    I$ *a#!# i$itia!# a!# 6!ii7 +# pat# +ta6i!i 3$ +', a,itti' p,#-i'ti/ -# #/!3ti# p#$t,3

    p#,ia-a -# 2 a$i7 /a!a,#a &ai&a a +',3!3i *ii$- J7 p,i$ #/a!3a,#a '3 'at# " p3$'t# a p,##$t#i

    *a't,3!3i ,#3&ati- +a3 a i$*!a&ati#i !a &ai &3!t -# " a,ti'3!atii a!# #t,#&itatii &6,3!3i

    +3p#,i,7 +i '3 'at# 1 p3$'t p,##$ta *#$$3!3i Ra$a3-7 a!t#,a,#a +ta,ii g#$#,a!#7 ,a+a a!6a7+#3! *#&i$i$. U$ +', '3 /a!a,#a 9" a,ata a6+#$ta 3!t#,ia,a a t3*i#,i!,7 /a!a,#a -# %92

    i$-i'a i$*!a&atii p,##$t# i$ /iit, +i +',3! -# 9J ,i#$t#aa a+3p,a apa,iti#i #,i3$i!,.

    Capacitatea !unctionala i$ PR -#pi$-# -# a'ti/itat#a i$*!a&at,i# a 6!ii +i -# a!t#,a,i!#

    &,*!gi'# ?-#*,&a,i7 a$'

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    4. 000 5 0 5

    Anemie

    *6 2%/-1%/ mil%6 .

    7emperatura

    189 000 .

    4 189 000 2 0 2

    la$ire intr-o luna

    /: 000 .

    4/: 000 2 0 2

    ;odo"itati

    putine 000 2

    numeroase 000 1 0 1

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    9 C,it#,ii!# ACR 9 #/!3tia piti/a a i$-i'i!, a,ti'3!a,i +i a!i,a,#a a % -i$t,# 3,&ata,#!#:

    ap,#'i#,#a pa'i#$t3!3i ap,#'i#,#a -i'3!3i VSH +'a!a -3,#,i!, '

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    9 S',3,i ,a-i!gi'#: S

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    52/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    Diag$+ti'3! p,#''# 'a,# +# 6a#a( 5$ &a,# pa,t# p# i$/#+tigaii pa,a'!i$i'# a,# 3$ ,!

    i&p,ta$t i$ #/!3ia7 p,g$+ti'3! +i t,ata$t3!7 a'#+t#i a*#'i3$i '3 +'p3! p,i,ii +a3 i$t8,i#,ii

    p,g,#+i#i p,'#+3!3i i$*!a&at, 4i a '$+#'i$#!, a'#+t3ia7 p#$t,3 a!i,a,#a 'a!it(ii /i#ii

    pa'i#$i!, '3 p!ia,t,it( ,#3&ati-(.

    III5 $5 M&t#r(&) ( #to-

    P#$t,3 #*#'t3a,#a a'#+t3i +t3-i37 a& *!+it t-a +tati+ti'( a+3p,a 3$3i !t -# -#

    pa'i#$i7 -iag$+ti'ai '3 p!ia,t,it( ,#3&ati-(7 p,#!38$- -at#!# -i$ *i!# -# 6+#,/ai#.Dat#!# 6i$3t# !#9a& '#$t,a!iat 4i p,#!3',at +tati+ti'7 p# 6aa !, *ii$- i$t'&it# ta6#!#!#

    4i g,a*i'#!# 3,&(ta,#.

    St3-i3! +9a -#,3!at 5$ 'a-,3! Spita!3!3i C!i$i' W3-##a$ -# U,g#$( Ti&i+a,a 9 C!i$i'a

    )#-i'a!( III Y D#pa,ta$t R#3&at!gi# 5$'#p8$- '3 -ata -# " 't&6,i# "J 4i a *+t

    *i$a!iat !a -ata -# 1J 't&6,i# ".

    $ i$t#,/a!3! " 't&6,i# "J Y1J ap,i!i# " +9a -#+*(43,at p#,ia-a -# i$'!3-#,# 5$

    +t3-i37 ti&p 5$ 'a,# a3 *+t #/a!3ai 3$ $3&(, -# 10 pa'i#$i ?" 6a,6ati 4i 2@ -iag$+ti'ai '3

    PR7 p,##$tai '$+#'3ti/ p#$t,3 +pita!ia,# -# i +a3 '$ti$3(.

    P,i&a /iit( -# +t3-i3 a *+t #*#'t3at( 5$ &$t3! +',##$i$g93!3i pa'i#$i!,. $ 'a-,3!

    a'#+t#i /iit# +9a3 6i$3t -at#!# -# i-#$ti*i'a,# a!# pa'i#$i!,7 +9a 3,&(,it

    5$-#p!i$i,#a ',it#,ii!, -# i$'!3-#,# 5$ +t3-i3 ?ta6#! 1@ 4i a6+#$a '#!, -# #'!3-#,# ?ta6#! "@7 +9a

    #*#'t3at a$a&$#a 4i #a$3! 6i#'ti/ a! a'#+t,a7 +9a3 '&p!#tat '

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    Nr5"rt5

    CRITERII DE INCLUDERE

    1 Diag$+ti' -# p!ia,t,it( ,#3&ati-( -3pa ',it#,ii!# ACR 1J ?5$-#p!i$i,#a a

    &i$i& 0 ',it#,ii -i$3,&(ta,#!# @:A. R#-a,# &ati$a!( ?5$ a,ti'3!ai# 4i 5$ ;3,3! #i@ '3 -3,at( -# '#! p3i$ 1 ,a7p,##$t( '#! p3i$ +(pt(&8$iB. A,t,it( !a '#! p3ti$ % $# a,ti'3!a,# +i&3!ta$ ?'3 t3*a'ia p(,ti!, &i +a3!i'

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    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    I$*#'i# '3$+'3t( 5$ 3!ti!# 0 +(pt(&8$i a$t#,i, /iit#i -# +',##$i$g )iit(J Ni/#!# -# ',#ati$*+*i$a( " ,i !i&ita +3p#,ia,( a /a!,i!, $,&a!# Ba!(

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    55/68

    Antohe Geta Elemente de prognostic n poliartrita reumatoid (PAR)

    $i$3t '$+ta$t( t#,apia D)ARD+ ?-i'a$t# &-i*i'ata,# -# 6a!(@ a$t#,ia,(. $ '3,+3!

    +t3-i3!3i +9a p#,&i+ a-&i$i+t,a,#a -# a$tii$*!a&at,ii $#+t#,i-i#$#7 -i'aia a*#'i3$i!,

    '#i+t#$t#7 p,#-$i+$ p#, + ?!a -# 1&gi@7 p,#'3& 4i a-&i$i+t,a,#a -# ',ti'i-

    i$t,aa,ti'3!a, ?-a, $3 5$ i$t#,/a!3! -# 0 +(pt(&8$i 5$ai$t# -# /iita -# +t3-i3 p#$t,3 a $3 i$*!3#$a#/a!3a,#a a'ti/it(ii 6!ii@.

    Dat#!# 6i$3t# 5$ 3,&a '#!, t,#i /iit# -# +t3-i3 a3 +#,/it !a '&p!#ta,#a 3$#i 6a# -#

    -at#7 a'#a+ta *ii$- ',#at( '3 a;3t,3! p,g,a&3!3i SPSS /. 1.7 p,g,a& 'a,# a *+t 3ti!iat 4i !a

    p,#!3',a,#a +tati+ti'( a -at#!,. A$a!ia -at#!, a *+t di$t#$ti$ t t,#at^ ?a$a!i( 5$ i$t#$ia -#

    t,ata,# Y ti pa'i#$ii ,a$-&iai a3 *+t a$a!iai 5$ !t3! 5$ 'a,# a3 *+t i$'!34i@7 pa'i#$ii 'a,#

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