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World history of Assisted

Human Reproduction

Asist. Univ. Dr. Raluca Tulin

Endocrinology/ Embryology Specialist

Profile: Anatomy

Embryology Department U!" #arol Davila$

Optional Course, Year VI- General MedicineClinical Embryology & Assisted Humaneproduction

Course 4


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%&'(

• )*rave ne+ +orld,- Aldou uley 0S"

novel reproduction ta1es place in 2incubation

center23


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%&'4

• 5regory Pincus '% years

old 2 Dr. "ran1enstein 2

and Dr. E67!A66

arvard 8 mied t9e sperm

and oocytes of rabbits in

+atc9 glass and t9e

embryo +as implanted insurrogate rabbits

• "irst )test8tube8rabbit,


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%&;

• #arl 5em


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%&&

• !in #9e9 #9ang - indubitable

evidence obtained of in vitro

fertili


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%&=' 8 Australia

• "irst 9uman pregnancy

!elbourne Australia

• #AR> ?@@D si @6

>EET@60gynecologists3

• Pregnancy stopped

progressing at an earlystage


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%&=B 8 UC

• Patric1 Steptoe

0gynecologist3

and Robert Ed+ards

0biologist3 publis9ed areport according to

+9ic9 9ad obtained an

ectopic pregnancy after

a transfer in morulastage 0in laboratory3


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1978 – First baby tube

• Patric1 Steptoe and Robert

Ed+ards @ld9am ospital

!anc9ester #ity UC

• >esley *ro+n o9n*ro+n - couples infertility

0& years3

• ?it9out ovarian stimulation

• >aparoscopy collection of

oocytes


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25 uly 1978! 2"#$7

• Pregnancy delivery- ';

+ee1s days• (=FF g

• >ouise *ro+n


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%&=;

• Ale >opata !elbourne Australia -

describes t9e first cycle stimulated +it9 clomip9ene citrate

0#lomid Serop9ene #lostylbegyt 3 .

• A non8steroid analog of estradiol 0 SER!s 8 selective estrogen

receptor modulator 3 eerts a stimulatory effect on ovarian

function in +omen +it9 anovulatory infertility

• FmgG'/day day'8= or 8&.

@vulation occurs 8; days after t9e last tablet. Documentation

from %4 to %; days after clomip9ene ovulation .

– Prolonged depletion of estrogen receptor 0T "

UTERH63


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#lomip9ene #itrate


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% I %&=& "irst HJ" boy

• %4.F%.%&=&

Alastair !acdonald

0'rd HJ" boy3

• #ourtney #ross 0(nd

HJ" baby3

0%B.%F.%&=;3


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%&=&

• "rance 8 insert trac1ing

ultrasound ovulatory

cycle 0lin1ed to t9e levelof estradiol


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( I %&;F - "irst Australian baby

• #andice Eli


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' I %&;% "irst American HJ" baby

• (;.%(. %&;% Eli


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' I %&;% Australia

• Alan Trounson and o9n >eeton:

– introduce clomip9ene citrate and 9!5 0 !enopur

menotropina8 Reprone !enogon Pergonal

="S / => 3 in ovarian stimulation protocols

– 6otices t9at t9e number of mature oocytes increase

after 9#5 administration 0 'B9 3

–

Time is reLuired bet+een oocyte collection andinsemination itself to allo+ oocytes to mature in

culture medium


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4 I %&;(•

6atalie *ro+n 04Ft9

HJ" c9ild3• "o#ember $%%%, ouise 'ro(n)s sister,

"atalie, ga#e birt* to a baby girl, t*e +rstbaby born to a parent *ersel concei#ed by

IV• "irst t+o HJ" "renc9 c9ildren 0Amandine 8

"ebruary Aleia8 une3

•

"irst S+edis9 c9ild0>a 5oteburg3


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4 I %&;(

• %B.F4 8 @livier %st HJ"

c9ild in Erlangen

5ermania

• 7latan ovanovic %st HJ"

c9ild in Austria JiennaAC ospital


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4 I%&;(

• Ric9ard "leming -

5nR agonists

0buserelin nafarelin

treptorelin leuprolid3

in9ibits pmature

maturation of t9e

ovocites


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• %&=; 8 UC

• %&;F 8 Australia

• %&;% 8 USA

• %&;( - "rance M S+eden


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I %&;'Alan Trounson Australia

• "irst pregnancy after embryos fro


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I %&;' %st HJ" triplets in Australia

• #9ristop9er #9en )"at9er of embryonic

free


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B I %&;4 %st HJ" Luadruplets

• =.F%.%&;4 !elbourneNs Royal ?omenNs

ospital


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B I %&;4

• T9e first c9ild born after

freeeyland

!elbourne Australia in

Oueen !edical #enter

• Alan Trounson and #arl

?ood


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B I %&;4

• "irst c9ild born from gestational carrier - non

genetically related to t9e c9ild #alifornia USA• “For her efforts Boff was paid $10,000 by Elliot and Sandy”

• Gestational surrogacy full surrogacy non geneticallyrelated to the child !"#F

• %raditional surrogacy genetic surrogacy &other is

genetically related to the child !natural, "'", F"#

• Endocrinologist Ricardo Asc9 first 5H"T 0translaparoscopic gamete intrafallopian transfer

05H"T3


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= I %&;

• "irst pregnancy after PESA

0percutaneous epididymal

sperm aspiration3

• Testarts group in "ranta -

free


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• European Society of uman Reproduction and

Embryology 0ESRE3 8 Robert Ed+ards 0UC3

si ean #o9en 0 Paris3 - since %&;


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; I %&;B

• >upron 05nR agonist3 - to

prevent premature ovulation

• "irst pregnancy after oocyte

donation to +omen before

menopause- Dr. 7ev

Rosen+a1s USA

• "irst TESE 0*ilateralobstruction of deferent

ducts3


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; I %&;B

• "irst pregnancy after

using cryopreserved

oocytes #9ristop9er

#9en in Australia 0slo+free


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& I %&;=• !elissa Stern 0*aby !3 +as born on!arc9 (=t9 in t9e United States.• er surrogate and biological mot9er

!ary *et9 ?9ite9ead 0+9o conceived

by artificial insemination3 refused to

yield custody of !elissa 0baby !3 to t9e

couple 0?illiam Stern and 9is +ife

Eli


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& I %&;=• %( une %&;=

• 6or+ay - first la+ of assisted 9uman

reproduction . HJ" limits t9e follo+ing:• !arried couples/ partners

• Same8se couples8 E#>UDED

• Single +omen 8 E#>UDED

• Surrogacy embryo donation8 E#>UDED


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%F I %&;;•

Patric1 Steptoe dies• "irst birt9 after !ESA 0*ilateral deferents ducts

agenesis3

• "irst birt9 +it9 oocytes donation from t9e mot9er of

t9e patient and sperm from donor


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%% I %&;&

• "irst Preimplantational se

diagnostic8 determining Q

c9romosome by P#R0Alan. andyside UC3


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%4I %&&(

• "irst pregnancy after H#SH 0intracytoplasmic

sperm inection3 8 5ianpiero Palermo and

Andre Jan8Steirteg9em in *russels *elgium


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% I %&&'

• "irst

pregnancyafter TESE

H#SH

S9erman

Silber

urologist


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%B I %&&4

• "irst triplet pregnancy 0boys3 and surrogate

mot9er 0after transferring ( embryos and

subseLuent division3 UC


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%; I %&&B

• "irst pregnancy after spermatid inection of

round or long in oocyte Simon "is9el

– "or 6@A patients


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%; I %&&B

• B "ebruary first c9ild born t9roug9 HJ" in

Romania 0Daniel Hoan3 -Team lead by Prof.

Dr. Hoan !unteanu Timisoara


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%& I%&&=

• TU6E> met9od 0terminal deoynucleotidyltransferase8mediated dUTP8biotin end labeling3 -

to detect D6A fragmentation and appreciation of

HJ" success Sun urisicova and Robert #asper

Toronto8 #anada


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(F I %&&;•

"irst pregnancy after TESE H#SH la Sd.Clinefelter

• "irst octuplets St >u1e ospital Teas 61em

#9u1+u and Hy1e >ouis Udobi


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(%I %&&&

• "irst pregnancy after P5D 0preimplantational

genetic diagnosis3 for sic1le cell anaemia-

biopsy 7' and ET 74


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011 boli


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(% I %&&&•

Denmar1 registers t9e 9ig9est number ofHJ"s/ million capita. 0%;(B3

• "inland 0%44F3

•

S+eden• 6or+ay

• Hceland


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(% I %&&&

• "irst pregnancy +it9 oocyte fro


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(( I (FFF

• T9e first transplant of

ovarian tissue Cutlu1

@1tay and 5uvenc

Carli1aya 6e+ Qor1 8in a patient (& years

!argaret >loyd8 art

dancer +9ose ovary+as fro


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(' I (FF%

Single8se procreation Australia 0H6 !@USE3


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(4 I (FF(

•"irst pregnancy after P5D+it9 blastocyst biopsy De

*oer C !cArt9ur


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( I(FF'

• Hntroduction SET 0single

embryo8transfer3

• "irst born c9ild after P5D

for retinoblastoma

0


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(= I (FF

• Adriana Hliescu BB years '(F days


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(=I(FF

• "irst c9ild born aftertrofectoderm biopsy and

P5D - for T9alassemia


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(; I (FFB

• #ryopreservation intact ovary

0 +it9 ovarian pedicle3

• !aria del #armen *ousada

BB years and '; days Spain

- t9e oldest t+in mot9er

• >ouise *ro+n gives birt9

0boy naturally concieved3


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(& I(FF=

• PasLuale Patri


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'FI(FF;

• T9e first t+ins born after

embryos t9a+ed oocytes

in t9e ovary after cancer

0' years3

• T9e +orldNs oldest

mot9er Rao Devi

>o9an =F Hndia


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T9e youngest mot9er in t9e +orld

September (=t9 %&''

• >ina !edina years

early puberty


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'% I (FF&

• 6adya Suleman 0'' years3 -second pair of

octuplets in t9e +orld. !edicul !ic9ael

Camrava 8e transferred %( embryos

subseLuently 9is license +as +it9dra+n


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14 children,

All throughIVF

OCTOMOM


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'( I (F%F


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'( I (F%F

• T9e oldest mot9er of triplets *9ateri Devi

BB years Hndia 0 "irst c9ildren one did not

survive 3


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'' I (F%%

• EmbryoScope P5D - first born in

#leavland @9io - #laire and #9arlotte

0identical t+ins3


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' I (F%'

• Robert Ed+ards dies %F April

• uman cloning report

• Cisspeptin for inducing ovulation


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• Cisspespsin produced

of T stimulates "Sand >

2re#ents 3H3O


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(F%

• Pregnancy rate increases to F 0from (F3

• Jitrification 0prevents t9e formation of ice

crystals3

• T9e +9ole family can 9ave a single HJ" cycle

0free


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Aprilie (F%

• 7ain Raani "irst c9ild born +it9 t9e 9elp of

stem cells 0ovarian cortical3


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